I travel by train, so I can help you there. You want to carry only what you can easily handle in one trip. That's a suitcase and a backpack, plus a purse. You will stow the suitcase overhead, so make sure it's not too heavy. Keep all your valuables in the backpack in a zipped compartment, and take both it and your purse with you any time you leave your seat for food or the restroom. They sell food in the dining car, usually just sandwiches on most routes, although some have a full dining service where they seat you with strangers and there are waiters.

Every train seat has an electrical outlet, so you can use laptops or charge other devices. The internet on trains, when offered, is usually really slow. I usually pack a lunch or dinner and bring a book.

I can't begin to guess where you should go and what you'll need when you get there. Do you have job skills? Friends you can stay with? If not, it's going to take a lot of money for hotels while you seek a place to live, then first and last month's rent plus perhaps a security deposit, all without any money coming in. You need to consider transportation to look for work and get to your job, so location is a huge factor.